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【摘要】 目的：探讨自体瘤苗治疗胃腺癌对患者免疫功能的影响及临床效应。方法：9例瘤苗组实体瘤术后患者应用自体瘤苗，并与对照组8例进行比较，对其疗效进行判断评价，检测治疗前后其NKC活性及CD+3、CD+4、CD+8水平。结果:实验组使用自体瘤苗治疗后,其NKC细胞的活性及CD+3、CD+4水平明显高于对照组及自身治疗前，其CD+8水平低于其他组；近期随诊其生存质量及疗效也明显优于治疗前及对照组。结论：莪术醇生物构建的自体瘤苗能增强胃癌患者的治疗效果，明显提高自身细胞免疫功能，副反应较小，是一种安全、有效、实用的辅助治疗方法。
【关键词】 莪术醇生物构建自体瘤苗 胃肿瘤 免疫功能
Recent Research on Therapeuctic Effects of Autologous Tumor Vaccine of Curcumenal Biological
Structure in Trentment of Patients with Late Carcinoma Ventriculi
GAO Peng1,XU Lichun，CHEN Ping,LIU Xiaodan，NI Qing，FANG Xiaohua,WANG Jiaxing,ZHOU Juan，LIU Lijuan,XU Xiangyu
1.Yangzhou Chinese Medicine Hosptial,Yangzhou 225002,China;
2.Yangzhou University Cooperation of Chinese and Western Medicine Research Institute,Yangzhou 225000,China;
3.Northern Jiangsu People's Hospital,Yangzhou 225000,China;
4.Yangzhou First People's Hopsital,Yangzhou 225000,China;
5.Nanjing Military Area Command Militarg Medicine Research Institute,Nanjing 210 000,China
［Abstract］Objective:It is probed that the vaiue of autologous tumor vaccine therapy for malignant solid tumours and observe the effect of autoturuour Vaccine replatation on the immunological function of these tumour of stomach patienfs.Methods:9 cases with tumor were treated with Autologous tumor vaccine by modified curcumol.And Another 8 cases were treated by surgery which served as control group.The TLc substes CD+3、CD+4、CD+8 and the active NK cell were tested before and after operation.Results:They were significantly different before and after treatment with autologous tumor vaccine.The ratio of the NKcell activity,CD+3 and CD+4 and subpopulations of the T-lymphocyte,ratio and life quality rose significantly after the treatment(P＜0.05).Conclusions:Vaccine by modified curcummenal therapy can restore cellular immunity so as to enhance the therapeutic efficacy,the clinical symptoms and sighs was significantly improved.
［Key words］Autologous tumor cell vacine by modified cucurma;Tumour of stomach;lmmunity function
肿瘤是严重威胁人类健康的一类疾病，在我国，胃癌的发病率和死亡率仍居恶性肿瘤之首，由于起病隐匿，平时症状不典型。部分III期患者虽然可以进行手术切除，但短期内复发率很高。临床确诊时已处于Ⅳ期的病人约占全部胃癌患者的10％-20％，由此失去了手术机会，化疗是其主要治疗手段，但晚期胃癌对化疗不甚敏感，疗效不太理想［1-3］。中药是祖国的瑰宝，如何将这一瑰宝与现代医学研究相结合，实行中西医结合治疗肿瘤，此是我们要努力探讨的问题。近年来肿瘤疫苗的研制已成为肿瘤防治领域的热点，采用自体瘤苗回植的特异性主动免疫疗法，提高机体的抗病能力，阻止肿瘤生长、扩散和复发是日前正在积极探索的生物反应调节剂疗法(biologicalresponse modifier therapy,BRMT)的重要内容之一。如何利用传统中药，将传统中药 | 
